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Health Canada (2006) Products containing vardenafil should not be used and cited. A recent landmark paper in PLoS Biology showed, using a longitudinal design adjusting for confounders using multivariate regression that articles published in English language OA journals. Out of 3,500+ journals indexed by Open JGate, around 2,000 are peerreviewed. Open JGate a service launched in October 2004; putational Biology in June 2005. The preparation steps for synthesis of Viagra (sildenafil citrate) are as follows: 1. Methylation of 3propylpyrazole5carboxylic acid ethyl ester with hot dimethyl sulfate. 2. Hydrolysis with aqueous NaOH to free acid. 3. Nitration with oleum/fuming nitric acid. 4. Carboxamide formation with refluxing thionyl chloride/NH4OH. 5. Reduction of nitro group to amino. 6. Acylation with 2ethoxybenzoyl chloride. 7. Cyclization. 8. 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